Local Specific Therapy of Experimental Pneumococcal Meningitis

1. In experimental Type I pneumococcal meningitis of dogs central cord involvement is common after the 2nd day of the disease. 2. These central cord lesions may progress toward extensive suppurative myelitis. 3. Abscesses are infrequent; they arise either as direct perivascular extensions of the meningeal disease or at the site of infected purpuric lesions. 4. In prolonged untreated meningitis of reinfected animals, nothing resembling the disappearance of exudate following crisis in pneumonia occurs. The tendency is toward organization. 5. Late lesions are characterized by the marked development of a perivascular clasmatocytic apparatus, similar to, but more extensive than that hitherto reported in experimental herpetic encephalitis.